* {
  box-sizing: border-box;
}
body {
  margin: 12px;
  font-family: Arial, sans-serif;
  color: #283b40;
  background: #f5f7f7;
}
header,
footer {
  background: #276c70;
  color: white;
  padding: 16px;
  border-radius: 7px;
  text-align: center;
}
h1 {
  margin: 0;
  font-size: 28px;
}
header p {
  margin: 8px 0 0;
}
footer {
  margin-top: 14px;
  font-size: 13px;
}
footer {
  display: flex;
  flex-wrap: wrap;
  align-items: center;
  justify-content: space-between;
  gap: 10px 24px;
  padding: 12px 18px;
  font-size: 14px;
}
footer p { margin: 0; line-height: 1.5; }
footer nav { display: flex; flex-wrap: wrap; justify-content: center; gap: 10px 22px; }
footer a { color: inherit; text-underline-offset: 3px; }
footer a:focus-visible { outline: 2px solid white; outline-offset: 4px; }
main {
  display: grid;
  grid-template-columns: 285px minmax(0, 1fr);
  gap: 14px;
  margin-top: 14px;
}
section,
details {
  background: white;
  border: 1px solid #d4dede;
  border-radius: 6px;
  padding: 12px;
  margin-bottom: 10px;
}
h2 {
  font-size: 17px;
  margin: 0 0 10px;
}
label {
  display: block;
  font-size: 15px;
  margin: 8px 0;
}
input[type="number"],
select {
  width: 100%;
  font: inherit;
  padding: 6px;
  border: 1px solid #9aa;
  border-radius: 4px;
}
input[type="range"] {
  width: 100%;
  accent-color: #276c70;
}
button {
  padding: 9px;
  margin: 6px 4px 0 0;
  background: #276c70;
  color: white;
  border: 0;
  border-radius: 4px;
  font-size: 15px;
  cursor: pointer;
}
.hint,
details p {
  font-size: 13px;
  line-height: 1.5;
}
summary {
  cursor: pointer;
  font-weight: bold;
}
article {
  min-width: 0;
}
.graphs {
  display: grid;
  grid-template-columns: 1fr 1fr;
  gap: 12px;
}
.plot {
  min-width: 0;
  height: 500px;
  border: 1px solid #d4dede;
  border-radius: 6px;
  overflow: hidden;
  background: white;
}
.protocol {
  height: 235px;
  margin-bottom: 12px;
}
#status {
  color: #9b3821;
}
[hidden] {
  display: none !important;
}
:focus-visible {
  outline: 3px solid #a65d0c;
  outline-offset: 2px;
}
@media (min-width: 1101px) {
  aside {
    max-height: calc(100vh - 135px);
    overflow-y: auto;
    padding-right: 4px;
  }
}
@media (max-width: 1100px) {
  .graphs {
    grid-template-columns: 1fr;
  }
}
@media (max-width: 700px) {
  main {
    grid-template-columns: 1fr;
  }
  h1 {
    font-size: 24px;
  }
}
@media (max-width: 480px) { footer { justify-content: center; } }

/* Pair related protocol controls to keep the panel compact. */
#protocolControls,
.control-pair {
  display: grid;
  grid-template-columns: repeat(2, minmax(0, 1fr));
  column-gap: 10px;
}
#protocolControls > div,
.control-pair > div {
  min-width: 0;
}

/* Keep each channel's conductance and reversal controls together. */
#controlsA,
#controlsB {
  display: grid;
  grid-template-columns: repeat(2, minmax(0, 1fr));
  column-gap: 10px;
}
#controlsA > div,
#controlsB > div {
  min-width: 0;
}

#agonistControls {
  display: grid;
  grid-template-columns: repeat(2, minmax(0, 1fr));
  column-gap: 10px;
}
#agonistControls > div {
  min-width: 0;
}

.channel-heading {
  display: flex;
  align-items: center;
  gap: 10px;
  margin-bottom: 8px;
}
.channel-heading h2 {
  flex: 0 0 auto;
  margin: 0;
}
.channel-heading select {
  flex: 1;
  width: 0;
  min-width: 0;
}

#achControls {
  display: grid;
  grid-template-columns: repeat(2, minmax(0, 1fr));
  column-gap: 10px;
}
#achControls > div {
  min-width: 0;
}

.references {
  padding-left: 18px;
  font-size: 13px;
  line-height: 1.5;
}
.references li {
  margin-bottom: 10px;
}

/* Keep paired controls aligned without subscripts changing label height. */
#protocolControls label,
#controlsA label,
#controlsB label {
  line-height: 20px;
  min-height: 20px;
}
#protocolControls label sub,
#controlsA label sub,
#controlsB label sub {
  position: relative;
  bottom: -0.25em;
  vertical-align: baseline;
  line-height: 0;
}
#hold,
#measure {
  height: 34px;
}

#gabaControls {
  display: grid;
  grid-template-columns: repeat(2, minmax(0, 1fr));
  column-gap: 10px;
}
#gabaControls > div {
  min-width: 0;
}