Publications

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2025

1.    Rannio S, Alageswaran S, & Sjöström PJ: Branch logic: Dendritic computations diversify inhibition. Neuron (2025) 113:2875-2877 [Full text]

2.    Dragsted LK, Alageswaran S, Suvrathan A, & Sjöström PJ: Extracellular stimulation in neocortex lacks specificity. microPublication Biology (2025), doi: 10.17912/MICROPUB.BIOLOGY.001539. [Full text]

3.    Thomazeau A, Rannio S, Brock JA, Wong HHW, & Sjöström PJ: Neocortical layer-5 tLTD relies on non-ionotropic presynaptic NMDA receptor signaling. eLife (2025) doi: 10.7554/elife.106284 [Full text]

4.    Chou CYC, Droogers WJ, Lalanne T, Fineberg E, Klimenko T, Owens H, & Sjöström PJ: Postsynaptic spiking determines anti-Hebbian LTD in visual cortex basket cells. Frontiers in Synaptic Neuroscience (2025) doi: 10.3389/fnsyn.2025.1548563. [Full text]

5.    Wong HHW, Watt AJ, & Sjöström PJ: Laser microsurgery for presynaptic interrogation. Nature Protocols (2025) doi: 10.1038/s41596-024-01125-5 [Full text]

6.    Chou CYC, Wong HHW, Guo C, Boukoulou KE, Huang C, Jannat J, Klimenko T, Li VY, Liang TA, Wu VC, & Sjöström PJ: Principles of visual cortex excitatory microcircuit organization. The Innovation (2025) 6(1):100735 [Full text]

2024

7.    McFarlan AR, Gomez I, Chou CYC, Alcolado A, Costa RP, & Sjöström, PJ: The short-term plasticity of VIP interneurons in motor cortex. Frontiers in Synaptic Neuroscience (2024) doi: 10.3389/fnsyn.2024.1433977 [Full text]

8.    Gruver KM, Jiao JW, Fields E, Song S, Sjöström PJ, & Watt AJ: Structured connectivity in the output of the cerebellar cortex. Nature Communications (2024) doi: 10.1038/s41467-024-49339-1. [Full text]

9.    Lamsa KP, Kirkwood A, Sjöström PJ: Editorial: Insights in synaptic neuroscience. Frontiers in Synaptic Neuroscience (2024) doi: 10.3389/fnsyn.2024.1432259 [Full text]

10. McFarlan AR, Guo C, Gomez I, Weinerman C, Liang TA, & Sjöström PJ: The spike-timing-dependent plasticity of VIP interneurons in motor cortex. Frontiers in Cellular Neuroscience (2024) doi: 10.3389/fncel.2024.1389094 [Full text]

11. Wong HH, Watt AJ, Sjöström PJ: Synapse-specific burst coding sustained by local axonal translation. Neuron (2024) 112:264-276. [Full text]

2023

12. Sjöström PJ: Editorial: Horizons in synaptic neuroscience. Frontiers in Synaptic Neuroscience (2023) doi: 10.3389/fnsyn.2023.1295640. [Full text]

13. Wong HH, Chou CYC, Watt AJ, & Sjöström PJ: Comparing mouse and human brains. eLife (2023) Jul 10;12:e90017 [Full text]

14. Watanabe A, Guo C, & Sjöström PJ. The developmental profile of visual cortex astrocytes. iScience (2023) doi: 10.1016/j.isci.2023.106828. [PDF]

15. McFarlan AR, Chou CYC, Watanabe A, Cherepacha N, Haddad M, Owens H, & Sjöström PJ: The plasticitome of cortical interneurons. Nature Reviews Neuroscience (2023) doi: 10.1038/s41583-022-00663-9 [Full text] [PDF]

2022

16. Nugent FS, Kirkwood A, Lupica CR, & Sjöström PJ: Editorial: The Synaptic Basis of Neuropathology. Frontiers in Synaptic Neuroscience (2022) doi: 10.3389/fnsyn.2022.1043480. [Full text]

17. Mizusaki BEP, Li SSY, Costa RP, and Sjöström PJ: Pre- and postsynaptically expressed spike-timing-dependent plasticity contribute differentially to neuronal learning. PLoS Computational Biology (2022) 18, e1009409. 10.1371/journal.pcbi.1009409. [Full text]

2021

18. Sjöström PJ: Grand Challenge at The Frontiers of Synaptic Neuroscience. Frontiers in Synaptic Neuroscience (2021) doi: 10.3389/fnsyn.2021.748937 [Full text]

19. Huber KM, Paoletti P, & Sjöström PJ: Editorial: Latest Advances on Excitatory Synapse Biology. Frontiers in Synaptic Neuroscience (2021) doi: 10.3389/fnsyn.2021.768651 [Full text].

20. Wong HHW, Camiré O, Sjöström PJ: The secret life of memory receptors. eLife (2021) 10:71178 DOI:10.7554/eLife.71178 [Full text]. Commentary on Lituma et al. 2021.

21. Zhou L, Nho K, Haddad M, Cherepacha N, Tubeleviciute-Aydin A, Tsai AP, Saykin AJ, Sjöström PJ, & LeBlanc AC: Rare CASP6N73T variant associated with hippocampal volume exhibits altered proteolytic activity, synaptic transmission defect, and neurodegeneration. Scientific Reports (2021) 11(1):12695 DOI: 10.1038/s41598-021-91367-0 [Full text]

22. Wong HHW, Rannio S, Jones V, Thomazeau A, Sjöström PJ: NMDA receptors in axons: there's no coincidence. The Journal of Physiology (2021) 599.2:367–387, (2020) doi: 10.1113/JP280059 [Full text] [PDF]

2020

23. Feldmeyer D, Wesseling JF, and Sjöström PJ: Editorial: Methods for Synaptic Interrogation. Frontiers in Synaptic Neuroscience (2020) 12:1-3 [PDF]

24.  Brock JA, Thomazeau A, Watanabe A, Li SSY, & Sjöström PJ: A Practical Guide to Using CV Analysis for Determining the Locus of Synaptic Plasticity. Frontiers in Synaptic Neuroscience (2020) 12:11 DOI: 10.3389/fnsyn.2020.00011 [PDF]

25.  Cela E & Sjöström PJ: A Step-by-Step Protocol for Optogenetic Kindling. Frontiers in Neural Circuits (2020) 14:3 DOI: 10.3389/fncir.2020.00003 [PDF]

2019

26.  Zhou L, Flores J, Noël A, Beauchet O, Sjöström PJ, & LeBlanc AC: Methylene blue inhibits Caspase-6 activity, and reverses Caspase-6-induced cognitive impairment and neuroinflammation in aged mice. Acta Neuropathologica Communications (2019) 16(1):210 DOI: 10.1186/s40478-019-0856-6 [PDF]

27.  Cela E & Sjöström PJ: Novel Optogenetic Approaches in Epilepsy Research. Frontiers in Neuroscience (2019) 13:947 DOI: 10.3389/fnins.2019.00947 [PDF]

28.  Cela E, McFarlan AR, Chung AJ, Wang T, Chierzi S, Murai KK, & Sjöström PJ: An Optogenetic Kindling Model of Neocortical Epilepsy. Scientific Reports (2019) 9:5236 [Full text] [Press release] [Medical Express] [Editor’s choice]

29.  Waddell S & Sjöström PJ: Neurobiology of learning and plasticity. Current Opinion in Neurobiology (2019) 54:iii-vi [Full text] [PDF]

2018

30.  Lalanne T, Oyrer J, Farrant M, & Sjöström PJ: Synapse type-dependent expression of calcium-permeable AMPA receptors. Frontiers in Synaptic Neuroscience (2018) doi: 10.3389/fnsyn.2018.00034 [Abstract]

31.  Reynolds S, Abrahamsson T, Sjöström PJ, Schultz SR, & Dragotti PL: CosMIC: A Consistent Metric for Spike Inference from Calcium Imaging. Neural Comput (2018) 30(10):2726-2756 doi: 10.1162/neco_a_01114 [Abstract] [PDF]

32.  Noël A, Zhou L, Foveau B, Sjöström PJ, & LeBlanc AC: Differential susceptibility of striatal, hippocampal and cortical neurons to Caspase-6. Cell Death and Differentiation (2018) 25:1319-1335 DOI:10.1038/s41418-017-0043-x [Abstract] [PDF]

33.  Bouvier G, Larsen R, Rodríguez-Moreno A, Paulsen O, & Sjöström PJ: Towards Resolving the Presynaptic NMDA Receptor Debate. Current Opinion in Neurobiology (2018) 51:1-7 DOI: 10.1016/j.conb.2017.12.020 [Abstract] [PDF]

2017

34.  Dore K, Stein IS, Brock JA, Castillo PE, Zito K, & Sjöström PJ: Unconventional NMDA Receptor Signaling. The Journal of Neuroscience (2017) 37(45):10800-10807 [PDF]

35.  Abrahamsson T, Chou YCC, Li SY, Mancino A, Costa RP, Brock JA, Nuro E, Buchanan KA, Elgar D, Blackman AV, Tudor-Jones A, Oyrer J, Farmer WT, Murai KK, & Sjöström PJ: Differential Regulation of Evoked and Spontaneous Release by Presynaptic NMDA Receptors. Neuron (2017) 96(4):839-855. [Abstract] [Video abstract] [PDF]

36.  Reynolds S, Abrahamsson T, Schuck R, Sjöström PJ, Schultz SR, Dragotti PL: ABLE: an Activity-Based Level Set Segmentation Algorithm for Two-Photon Calcium Imaging Data. eNeuro (2017) 4(5) ENEURO.0012-17.2017 [Full text]

37.  Costa RP, Mizusaki BEP, Sjöström PJ, & van Rossum MCW: Functional consequences of pre- and postsynaptic expression of synaptic plasticity. Philosophical Transactions of the Royal Society B: Biological Sciences (2017) 372(1715) [Full text] bioRxiv (2016) DOI: 10.1101/075317 [Preprint]

2016

38.  Abrahamsson T, Lalanne T, Watt AJ, & Sjöström PJ: In-Vitro Investigation of Synaptic Plasticity. Cold Spring Harb Protoc (2016) 10.1101/pdb.top087262 [Intro] [Cover] [PMC Canada]

39.  Abrahamsson T, Lalanne T, Watt AJ, & Sjöström PJ: Long-Term Potentiation by Theta-Burst Stimulation Using Extracellular Field Potential Recordings in Acute Hippocampal Slices. Cold Spring Harb Protoc (2016) 10.1101/pdb.prot091298 [Abstract] [PMC Canada]

40.  Lalanne T, Abrahamsson T, & Sjöström PJ: Using Multiple Whole-Cell Recordings to Study Spike-Timing-Dependent Plasticity in Acute Neocortical Slices. Cold Spring Harb Protoc (2016) 10.1101/pdb.prot091306 [Abstract] [PMC Canada]

41.  Mizusaki BEP, Stepanyants A, Chklovskii DB, & Sjöström PJ: Neocortex: a lean mean memory storage machine. Nature Neuroscience (2016) 19(5):643-644 [PDF]. Commentary on Brunel Nature Neuroscience 2016.

42.  Farmer WT, Abrahamsson T, Chierzi S, Lui C, Zaelzer C, Jones EV, Ponroy Bally B, Chen GG, Théroux JF, Peng J, Bourque CW, Charron F, Ernst C, Sjöström PJ, & Murai KK: Neurons Diversify Astrocytes in the Adult Brain Through Sonic Hedgehog Signaling. Science (2016) 351(6275):849-854 DOI: 10.1126/science.aab3103 [Abstract] [Perspective by Stevens and Muthukumar]

43.  Lalanne T, Oyrer J, Mancino A, Gregor E, Chung A, Huynh L, Burwell S, Maheux J, Farrant M, & Sjöström PJ: Synapse-specific expression of calcium-permeable AMPA receptors in neocortical layer 5. The Journal of Physiology (2016) 594(4):837-861. (Editor's Choice) [Abstract] [PDF]

2015

44.  Larsen RS & Sjöström: Synapse-type-specific plasticity in local circuits. Current Opinion in Neurobiology (2015) 35:127-135. [Abstract] [PMC Canada] [PDF]

45.  Costa RP, Froemke RC, Sjöström PJ, & van Rossum MCW: Unified pre- and postsynaptic long-term plasticity enables reliable and flexible learning. eLife (2015) DOI:10.7554/eLife.09457. [Abstract] [ModelDB]

2014

46.  Ferreira TA, Blackman AV, Oyrer J, Jayabal S, Chung AJ, Watt AJ, Sjöström PJ, & van Meyel DJ: Neuronal morphometry directly from bitmap images. Nature Methods (2014) 11(10):982-984, DOI:10.1038/nmeth.3125. [Abstract] [PMC Canada]

47.  Blackman AV, Grabuschnig S, Legenstein R, & Sjöström PJ: A comparison of manual neuronal reconstruction from biocytin histology or 2-photon imaging: morphometry and computer modeling. Frontiers in Neuroanatomy (2014) 8:65, DOI: 10.3389/fnana.2014.00065. [Abstract]

2013

48.  Blackman AV, Abrahamsson T, Costa RP, Lalanne T, & Sjöström PJ: Target-cell-specific short-term plasticity in local circuits. Frontiers in Synaptic Neuroscience (2013) 5:11, DOI: 10.3389/fnsyn.2013.00011. [Abstract]

49.  Costa RP, Sjöström PJ, & van Rossum MCW: Probabilistic inference of short-term synaptic plasticity in neocortical microcircuits. Frontiers in Computational Neuroscience (2013) 7:75, DOI:10.3389/fncom.2013.00075. [Abstract] [ModelDB]

50.  Costa RP, Watt AJ, & Sjöström PJ: How to train a neuron. eLife (2013) 2:e00491, DOI: 10.7554/eLife.00491. Commentary on Pawlak et al, eLife 2013.

2012

51.  Buchanan KA, Blackman AV, Moreau AW, Elgar D, Costa RP, Lalanne T, Tudor Jones AA, Oyrer J, & Sjöström PJ: Target-Specific Expression of Presynaptic NMDA Receptors in Neocortical Microcircuits. Neuron (2012) 75:451-466. [Full] [PDF]

52.  Markram H, Gerstner W, & Sjöström PJ: Spike-timing-dependent plasticity: a comprehensive overview. Frontiers in Synaptic Neuroscience (2012) 4(2):1-3. [Full]

2011

53.  Costa RP, & Sjöström PJ: One cell to rule them all, and in the dendrites bind them. Frontiers in Synaptic Neuroscience (2011) 3(5):1-2. [Full]

54.  Markram H, Gerstner MW & Sjöström PJ: A history of spike-timing-dependent plasticity. Frontiers in Synaptic Neuroscience (2011) 3(4):1-24. [Abstract]

55.  Ko H, Hofer SB, Pichler B, Buchanan KA, Sjöström PJ, & Mrsic-Flogel T: Functional specificity of local synaptic connections in neocortical networks. Nature (2011) 473:87-91. [Abstract]

2010

56.  Sjöström PJ & Gerstner W: Spike-timing dependent plasticity. Scholarpedia (2010) 5(2):1362.

57.  Buchanan KA & Sjöström PJ: A piece of the neocortical puzzle: the pyramid-Martinotti cell reciprocating principle. The Journal of Physiology (2009) 587.22:5301-5302. Perspective on Berger et al.

58.  Watt AJ, Cuntz H, Mori M, Nusser Z, Sjöström PJ, & Häusser M: Traveling waves in developing cerebellar cortex mediated by asymmetrical Purkinje cell connectivity. Nature Neuroscience (2009) 12:463-473. [Abstract] [Faculty of 1000]

59.  Sjöström PJ, Rancz EA, Roth A, & Häusser M: Dendritic Excitability and Synaptic Plasticity. Physiological Reviews (2008) 88:769-840. Abstract

60.  Sjöström PJ, Turrigiano GG, & Nelson SB: Multiple forms of long-term plasticity at unitary neocortical layer 5 synapses. Neuropharmacology (2007) 52:176-184. Abstract PDF

61.  Varshney LR, Sjöström PJ, Chklovskii DB: Optimal Information Storage in Noisy Synapses under Resource Constraints. Neuron (2006) 52:409-423. Abstract

62.  Sjöström PJ & Häusser M: A cooperative switch determines the sign of synaptic plasticity in distal dendrites of neocortical pyramidal neurons. Neuron (2006) 20:227-238. Abstract Commentary PDF

63.  Duguid I & Sjöström PJ: Novel presynaptic mechanisms for coincidence detection in synaptic plasticity. Current Opinion in Neurobiology (2006) 16:312-22. Abstract

64.  Song S, Sjöström PJ, Reigl M, Nelson S, Chklovskii DB: Highly Nonrandom Features of Synaptic Connectivity in Local Cortical Circuits. PLoS Biology (2005) 3:507-519. Full-text article Synopsis

65.  Sjöström PJ, Turrigiano GG, Nelson SB: Endocannabinoid-dependent neocortical layer-5 LTD in the absence of postsynaptic spiking. Journal of Neurophysiology (2004) 923:3338-3343. Abstract

66.  Watt AJ, Sjöström PJ, Häusser M, Nelson SB, Turrigiano GG: A proportional but slower NMDA potentiation follows AMPA potentiation in LTP. Nature Neuroscience (2004) 7:518-524. Abstract

67.  Sjöström PJ, Turrigiano GG, Nelson SB: Neocortical LTD via coincident activation of presynaptic NMDA and cannabinoid receptors. Neuron (2003) 39:641-654. Abstract Commentary

68.  Nelson SB, Sjöström PJ, Turrigiano GG: Rate and timing in cortical synaptic plasticity. Phil. Trans. R. Soc. Lond. B (2002) 357:1851-1857. Abstract

69.  Sjöström PJ, Nelson SB: Spike timing, calcium signals and synaptic plasticity. Current Opinion in Neurobiology (2002) 12:305-314. Abstract

70.  Sjöström PJ, Turrigiano GG, Nelson SB: Rate, Timing, and Cooperativity Jointly Determine Cortical Synaptic Plasticity. Neuron (2001) 32:1149-1164. Abstract Commentary PDF

71.  Sjöström, Jesper: Lysenko och Kreationismen. [HTML] Folkvett, 3-4:6-20 (1999). (Journal of the Swedish skeptic society Föreningen för Vetenskap & Folkbildning.)

72.  Sjöström PJ, Frydel BR, Wahlberg LU: Artificial Neural Network-Aided Image Analysis System for Cell Counting. Cytometry, 36:18-26 (1999). Abstract

Technical Reports

1.     Wilms C, Abrahamsson T, & Sjöström PJ: Simultaneously recording from four neurons using PatchStar and MicroStar manipulators. Scientifica SciNote 2016 [PDF][Quadruple patch clamp movie]

Book Chapters

1.     Abrahamsson T, Lalanne T, Watt AJ, & Sjöström PJ: In-vitro investigation of synaptic plasticity. In Ion Channels: A Laboratory Manual, 1st edition (2017) Eds. Duguid I, Kammermeier P, Brenowitz S, CSH Press. [At Amazon]

2.     Maheux J, Froemke RC, & Sjöström PJ: Functional plasticity at dendritic synapses. In Dendrites, 3rd ed (April 2016) Eds. Greg Stuart, Nelson Spruston, Michael Häusser, Oxford University Press. [At Google Books]

3.     Blackman AV, Grabuschnig S, Legenstein R, & Sjöström PJ: A comparison of manual neuronal reconstruction from biocytin histology or 2-photon imaging: morphometry and computer modeling. In Quantitative Analysis of Neuroanatomy. (2016) Eds. Budd JML, Cuntz H, Gelen SJ, & Krieger P, Frontiers Media SA, ISBN: 978-2-88919-796-5. [PDF]

4.     Sjöström PJ: Lysenko och kreationisterna. In Fakta eller fantasier. Föreställningar i vetenskapens gränstrakter, Ed. J. Jerkert, Leopard förlag, 2007.

Books

1.    Huber KM, Paoletti P, Sjöström PJ: Latest Advances on Excitatory Synapse Biology. Frontiers Research Topic eBook (2021) 332 pages, ISBN 978-2-88971-681-4, Frontiers Media SA, Lausanne, Switzerland. [Link]

2.    Sjöström P (Ed): Frontiers in Synaptic Neuroscience - Editor's Pick 2021. Frontiers Research Topic eBook (2021) 168 pages, ISBN 978-2-88971-065-2, Frontiers Media SA, Lausanne, Switzerland. [Link]

3.    Feldmeyer D, Wesseling JF, & Sjöström P (Eds): Methods for Synaptic Interrogation. Frontiers Research Topic eBook (2020) 276 pages, ISBN: 978-2-88963-864-2, Frontiers Media SA, Lausanne, Switzerland. [Link]

4.     Markram H, Gerstner W, & Sjöström PJ (Eds): Spike-timing-dependent plasticity: a comprehensive overview. Frontiers Research Topic eBook (2012) 575 pages, ISBN: 978-2-88919-043-0, Frontiers Media SA. [Link]

Editorial Work

1.     Sjöström PJ, Park H, Dudek SM, Bramham CR, Chou CYC: Research Topic in Frontiers in Synaptic Neuroscience, The diversity of the plasticitome, 12 articles, Dec 2024 – present.

2.     Sjöström PJ, Nugent F, Lupica C, Kirkwood A: Research Topic in Frontiers in Synaptic Neuroscience, The Synaptic Basis of Neuropathology, 14 articles, Sept 2021 – 2022.

3.     Sjöström PJ: Research Topic in Frontiers in Synaptic Neuroscience, Editor’s Pick 2021, Apr 2021

4.     Huber KM, Paoletti P, Sjöström PJ: Research Topic in Frontiers in Synaptic Neuroscience on Latest Advances on Excitatory Synapse Biology, 13 articles, July 2019 – August  2021.

5.     Waddell S, Sjöström PJ: Guest Section Editor for Special Issue 54 on The Neurobiology of Learning and Plasticity Feb 2019 in Current Opinion in Neurobiology, 26 articles.

6.     Feldmeyer D, Wesseling JF, Sjöström PJ: Research Topic in Frontiers in Synaptic Neuroscience on Methods for Synaptic Interrogation, 20 articles, Jan 2018 – June 2020.

7.     Sjöström PJ and other Specialty Chief Editors: Research Topic in Frontiers in Synaptic Neuroscience on 10 Years of Impactful, Open Neuroscience, 2017-2019.

8.     Markram H, Gerstner W, Sjöström PJ: Research Topic in Frontiers in Synaptic Neuroscience on Spike-timing dependent plasticity, 32 articles, 2010-2011.

9.     Markram H, Gerstner W, Sjöström PJ: Research Topic in Frontiers in Computational Neuroscience on Theory and models of spike-timing dependent plasticity, 13 articles, 2010-2011.